Zebrafish fin regeneration after cryoinjury-induced tissue damage

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Zebrafish fin regeneration after cryoinjury-induced tissue damage

Although fin regeneration following an amputation procedure has been well characterized, little is known about the impact of prolonged tissue damage on the execution of the regenerative programme in the zebrafish appendages. To induce histolytic processes in the caudal fin, we developed a new cryolesion model that combines the detrimental effects of freezing/thawing and ischemia. In contrast to...

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The zebrafish fin provides a valuable model to study the epimorphic type of regeneration, whereby the amputated part of the appendage is nearly perfectly replaced. To accomplish fin regeneration, two reciprocally interacting domains need to be established at the injury site, namely a wound epithelium and a blastema. The wound epithelium provides a supporting niche for the blastema, which contai...

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Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish.

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ژورنال

عنوان ژورنال: Biology Open

سال: 2016

ISSN: 2046-6390

DOI: 10.1242/bio.016865